Silver nanoparticle induced toxicity and cell death mechanisms in embryonic zebrafish cells
نویسندگان
چکیده
From their first contact with continuously cultured ZF4 cells, 10, 30 and 100 nm PVP-capped AgNPs induce receptor mediated endocytotic processes, cellular repair mechanisms, at higher doses, cell death via autophagy, apoptosis or necrosis.
منابع مشابه
Comparative metal oxide nanoparticle toxicity using embryonic zebrafish
Engineered metal oxide nanoparticles (MO NPs) are finding increasing utility in the medical field as anticancer agents. Before validation of in vivo anticancer efficacy can occur, a better understanding of whole-animal toxicity is required. We compared the toxicity of seven widely used semiconductor MO NPs made from zinc oxide (ZnO), titanium dioxide, cerium dioxide and tin dioxide prepared in ...
متن کاملMolecular Mechanisms of Toxicity of Silver Nanoparticles in Zebrafish Embryos
Silver nanoparticles cause toxicity in exposed organisms and are an environmental health concern. The mechanisms of silver nanoparticle toxicity, however, remain unclear. We examined the effects of exposure to silver in nano-, bulk-, and ionic forms on zebrafish embryos (Danio rerio) using a Next Generation Sequencing approach in an Illumina platform (High-Throughput SuperSAGE). Significant alt...
متن کاملInduced tissue cell death by magnetic nanoparticle hyperthermia for cancer treatment: an in silico study
In this paper, we simulate magnetic hyperthermia process on a mathematical phantom model representing cancer tumor and its surrounding healthy tissues. The temperature distribution throughout the phantom model is obtained by solving the bio-heat equations and the consequent cell death amount is calculated using correlations between the tissue local temperature and the cell death rate. To have a...
متن کاملSilver Nanoparticle Exposure Induced Mitochondrial Stress, Caspase-3 Activation and Cell Death: Amelioration by Sodium Selenite
Silver nanoparticles (AgNP), one of the most commonly used engineered nanomaterial for biomedical and industrial applications, has shown a toxic potential to our ecosystems and humans. In this study, murine hippocampal neuronal HT22 cells were used to delineate subcellular responses and mechanisms to AgNP by assessing the response levels of caspase-3, mitochondrial oxygen consumption, reactive ...
متن کاملMechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity
The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. The unique physicochemical and electrical properties of engineered nanoparticles (NP) make them highly desirable in a variety of applications. However, these novel properties of NP are fraught with concerns for environmental and occupational exposure. Changes in stru...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanoscale
سال: 2021
ISSN: ['2040-3372', '2040-3364']
DOI: https://doi.org/10.1039/d0nr09024g